Disseminated Nontuberculous Mycobacteriosis Caused by Mycobacterium kansasii in a Patient with Myelodysplastic Syndrome

Takuya KOMENO; Takayoshi ITOH; Kouji OHTANI; Masaharu KAMOSHITA; Yuichi HASEGAWA; Mitsuo HORI; Toshitaka KOBAYASHI; Toshiro NAGASAWA; Tsukasa ABE

doi:10.2169/internalmedicine.35.323

Disseminated Nontuberculous Mycobacteriosis Caused by Mycobacterium kansasii in a Patient with Myelodysplastic Syndrome

Takuya KOMENO, Takayoshi ITOH, Kouji OHTANI, Masaharu KAMOSHITA, Yuichi HASEGAWA, Mitsuo HORI, Toshitaka KOBAYASHI, Toshiro NAGASAWA, Tsukasa ABE

Author information

Takuya KOMENO
The Division of Hematology, Institute of Clinical Medicine, University of Tsukuba
Takayoshi ITOH
The Division of Hematology, Institute of Clinical Medicine, University of Tsukuba
Kouji OHTANI
The Division of Hematology, Institute of Clinical Medicine, University of Tsukuba
Masaharu KAMOSHITA
The Division of Hematology, Institute of Clinical Medicine, University of Tsukuba
Yuichi HASEGAWA
The Division of Hematology, Institute of Clinical Medicine, University of Tsukuba
Mitsuo HORI
The Division of Hematology, Institute of Clinical Medicine, University of Tsukuba
Toshitaka KOBAYASHI
The Division of Hematology, Institute of Clinical Medicine, University of Tsukuba
Toshiro NAGASAWA
The Division of Hematology, Institute of Clinical Medicine, University of Tsukuba
Tsukasa ABE
The Division of Hematology, Institute of Clinical Medicine, University of Tsukuba

Keywords: atypical mycobacteriosis, granuloma, lymphadenopathy, opportunistic infection, leukemoid reaction

JOURNAL FREE ACCESS

1996 Volume 35 Issue 4 Pages 323-326

DOI https://doi.org/10.2169/internalmedicine.35.323

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Abstract

A 38-year-old man with pancytopenia due to myelodysplastic syndrome exhibited persistent pyrexia and mediastinal lymphadenopathy. A biopsy specimen of the lymph nodes showed diffuse infiltration of epitheloid cells, including acid-fast bacilli identified as Mycobacterium kansasii. Cultures from gastric lavage and stool yielded M. kansasii, and granulomas were found in the bone marrow. A diagnosis of disseminated nontuberculous mycobacteriosis (DNTM) was established. The patient's condition improved after treatment with isoniazid, rifampicin, ethambutol and granulocyte colony-stimulating factor. Although DNTM due to M. kansasii is rare in Japan, it should be recognized as a possible cause of opportunistic infections.
(Internal Medicine 35: 323-326, 1996)

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