Takayasu's Arteritis Associated with Ulcerative Colitis; Genetic Factors in this Association

Yoshitaka MORITA; Masahiro YAMAMURA; Kinichiro SUWAKI; Atsushi MIMA; Tsutomu ISHIZU; Mamoru HIROHATA; Naoki KASHIHARA; Hirofumi MAKING; Zensuke OTA

doi:10.2169/internalmedicine.35.574

Yoshitaka MORITA, Masahiro YAMAMURA, Kinichiro SUWAKI, Atsushi MIMA, Tsutomu ISHIZU, Mamoru HIROHATA, Naoki KASHIHARA, Hirofumi MAKING, Zensuke OTA

Author information

Yoshitaka MORITA
The Third Department of Internal Medicine, Okayama University Medical School
Masahiro YAMAMURA
The Third Department of Internal Medicine, Okayama University Medical School
Kinichiro SUWAKI
The Department of Internal Medicine, Mitoyo General Hospital
Atsushi MIMA
The Department of Internal Medicine, Mitoyo General Hospital
Tsutomu ISHIZU
The Department of Internal Medicine, Mitoyo General Hospital
Mamoru HIROHATA
The Department of Internal Medicine, Mitoyo General Hospital
Naoki KASHIHARA
The Third Department of Internal Medicine, Okayama University Medical School
Hirofumi MAKING
The Third Department of Internal Medicine, Okayama University Medical School
Zensuke OTA
The Third Department of Internal Medicine, Okayama University Medical School

Keywords: human leukocyte antigens (HLA)-B52, HLA-DR2

JOURNAL FREE ACCESS

1996 Volume 35 Issue 7 Pages 574-578

DOI https://doi.org/10.2169/internalmedicine.35.574

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Abstract

Both ulcerative colitis and Takayasu's arteritis are thought to be organ-specific immunemediated inflammatory diseases. We present the rare case of a 23-year-old woman with a 4-year history of ulcerative colitis who developed Takayasu's arteritis one month after giving birth. She was found to carry the human leukocyte antigens (HLA)-B52 and DR2, which were previously noted to be associated with these inflammatory conditions in the Japanese population. The pathogenic relevance of this haplotype to the concomitant development of these two conditions is discussed.
(Internal Medicine 35: 574-578, 1996)

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