Apheresis Therapy for Prolonged Red Cell Aplasia after Major ABO-Mismatched Bone Marrow Transplantation

Satoshi OHTA; Hitoshi YOKOYAMA; Takuyuki ISE; Kazuya TAKASAWA; Takashi WADA; Sinji NAKAO; Tamotsu MATSUDA; Ken-ichi KOBAYASHI

doi:10.2169/internalmedicine.36.487

Satoshi OHTA, Hitoshi YOKOYAMA, Takuyuki ISE, Kazuya TAKASAWA, Takashi WADA, Sinji NAKAO, Tamotsu MATSUDA, Ken-ichi KOBAYASHI

Author information

Satoshi OHTA
The Division of Blood Purification, Kanazawa University
The First Department of Internal Medicine, Kanazawa University
Hitoshi YOKOYAMA
The Division of Blood Purification, Kanazawa University
Takuyuki ISE
The Division of Blood Purification, Kanazawa University
Kazuya TAKASAWA
The Division of Blood Purification, Kanazawa University
Takashi WADA
The Division of Blood Purification, Kanazawa University
The First Department of Internal Medicine, Kanazawa University
Sinji NAKAO
The Third Department of Internal Medicine, Kanazawa University
Tamotsu MATSUDA
The Third Department of Internal Medicine, Kanazawa University
Ken-ichi KOBAYASHI
The Division of Blood Purification, Kanazawa University
The First Department of Internal Medicine, Kanazawa University

Keywords: delayed red blood cell (RBC) recovery, double filtration plasma pheresis (DFPP), immunoadsorption

JOURNAL FREE ACCESS

1997 Volume 36 Issue 7 Pages 487-491

DOI https://doi.org/10.2169/internalmedicine.36.487

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Abstract

Two cases of leukemia were treated successfully with apheresis for delayed recovery of erythropoiesis due to antibody-mediated red cell aplasia after ABO-mismatched bone marrow transplantation (BMT). A 25-year-old female (ABO group O) underwent BMT from her brother (group A). Immunoadsorption using Biosynsorb A performed on day 146 after BMT followed by double filtration plasma pheresis (DFPP) reduced anti-A antibody titers from 1:32 to 1:2. Anemia improved dramatically within 2 weeks. A 49-year-old female (group O) underwent BMT from her mother (group A). She was treated with DFPP on day 131 after BMT. Anti-A antibody titers dropped from 1:16 to 1:1 and anemia improved gradually.
(Internal Medicine 36: 487-491, 1997)

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