Islet Cell Tumor in von Hippel-Lindau Disease

Nobumasa MIZUNO; Satoru NARUSE; Motoji KITAGAWA; Hiroshi ISHIGURO; Yasuyuki NAKAE; Hideaki IEDA; Naohiko IIZUKA; Osamu ITO; Yasunaga SEKI; Shigeru B.H. KO; Toshiyuki YOSHIKAWA; Tetsuo HAYAKAWA; Tsuyoshi SANO; Junichi KAMIYA; Yuji NIMURA; Testsuro NAGASAKA

doi:10.2169/internalmedicine.37.295

Nobumasa MIZUNO, Satoru NARUSE, Motoji KITAGAWA, Hiroshi ISHIGURO, Yasuyuki NAKAE, Hideaki IEDA, Naohiko IIZUKA, Osamu ITO, Yasunaga SEKI, Shigeru B.H. KO, Toshiyuki YOSHIKAWA, Tetsuo HAYAKAWA, Tsuyoshi SANO, Junichi KAMIYA, Yuji NIMURA, Testsuro NAGASAKA

Author information

Nobumasa MIZUNO
The Departments of Internal Medicine II, Nagoya University School of Medicine
Satoru NARUSE
The Departments of Internal Medicine II, Nagoya University School of Medicine
Motoji KITAGAWA
The Departments of Internal Medicine II, Nagoya University School of Medicine
Hiroshi ISHIGURO
The Departments of Internal Medicine II, Nagoya University School of Medicine
Yasuyuki NAKAE
The Departments of Internal Medicine II, Nagoya University School of Medicine
Hideaki IEDA
The Departments of Internal Medicine II, Nagoya University School of Medicine
Naohiko IIZUKA
The Departments of Internal Medicine II, Nagoya University School of Medicine
Osamu ITO
The Departments of Internal Medicine II, Nagoya University School of Medicine
Yasunaga SEKI
The Departments of Internal Medicine II, Nagoya University School of Medicine
Shigeru B.H. KO
The Departments of Internal Medicine II, Nagoya University School of Medicine
Toshiyuki YOSHIKAWA
The Departments of Internal Medicine II, Nagoya University School of Medicine
Tetsuo HAYAKAWA
The Departments of Internal Medicine II, Nagoya University School of Medicine
Tsuyoshi SANO
The Departments of Surgery I, Nagoya University School of Medicine
Junichi KAMIYA
The Departments of Surgery I, Nagoya University School of Medicine
Yuji NIMURA
The Departments of Surgery I, Nagoya University School of Medicine
Testsuro NAGASAKA
The Division of Pathology Clinical Laboratory, Nagoya University Hospital

Keywords: pancreatic polypeptide producing tumor, hemangioblastoma

JOURNAL FREE ACCESS

1998 Volume 37 Issue 3 Pages 295-299

DOI https://doi.org/10.2169/internalmedicine.37.295

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Abstract

We describe a 42-year-old man with von Hippel-Lindau disease and islet cell tumor of the pancreas. He had retinal and cerebellar hemangioblastomas. His sister had pheochromocytoma. A pancreatic tumor was detected by ultrasonography at his periodical medical checkup. Contrast enhanced computed tomography and abdominal angiography revealed a hypervascular tumor in the pancreatic head. Histological examination of the resected tumor revealed characteristics of islet cell tumor of the pancreas, which was positive for chromogranin-A, S-100 protein, and pancreatic polypeptide, but was negative for insulin, gastrin, glucagon, somatostatin, vasoactive intestinal peptide, serotonin, and adrenocorticotropic hormone.
(Internal Medicine 37: 295-299, 1998)

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