Type 1 Diabetes Mellitus Caused by Treatment with Interferon-β

Seijiro KADO; Jiro MIYAMOTO; Norie KOMATSU; Yoshiki IWAKI; Hirofumi OZAKI; Hirohisa TAGUCHI; Masahiko KURE; Gen SARASHINA; Toshiya WATANABE; Yoshiya KATSURA; Yoko NEMOTO; Masayuki NORITAKE; Takeshi MATSUOKA

doi:10.2169/internalmedicine.39.146

Seijiro KADO, Jiro MIYAMOTO, Norie KOMATSU, Yoshiki IWAKI, Hirofumi OZAKI, Hirohisa TAGUCHI, Masahiko KURE, Gen SARASHINA, Toshiya WATANABE, Yoshiya KATSURA, Yoko NEMOTO, Masayuki NORITAKE, Takeshi MATSUOKA

Author information

Seijiro KADO
the Department of Internal Medicine 5, Tokyo Medical University
Jiro MIYAMOTO
Miyamoto Hospital
Norie KOMATSU
Miyamoto Hospital
Yoshiki IWAKI
the Department of Internal Medicine 5, Tokyo Medical University
Hirofumi OZAKI
the Department of Internal Medicine 5, Tokyo Medical University
Hirohisa TAGUCHI
the Department of Internal Medicine 5, Tokyo Medical University
Masahiko KURE
the Department of Internal Medicine 5, Tokyo Medical University
Gen SARASHINA
the Department of Internal Medicine 5, Tokyo Medical University
Toshiya WATANABE
the Department of Internal Medicine 5, Tokyo Medical University
Yoshiya KATSURA
the Department of Internal Medicine 5, Tokyo Medical University
Yoko NEMOTO
the Department of Internal Medicine 5, Tokyo Medical University
Masayuki NORITAKE
the Department of Internal Medicine 5, Tokyo Medical University
Takeshi MATSUOKA
the Department of Internal Medicine 5, Tokyo Medical University

Keywords: GAD antibody, chronic hepatitis, hepatitis C virus, human leukocyte antigen

JOURNAL FREE ACCESS

2000 Volume 39 Issue 2 Pages 146-149

DOI https://doi.org/10.2169/internalmedicine.39.146

Details

Abstract

A 57-year-old man was referred to our outpatient clinic after interferon-β (IFN-β) treatment for 7 weeks. While IFN-β therapy was continued in our outpatient clinic, his blood glucose level increased gradually, and he was admitted to our hospital for hyperglycemia. The patient was prescribed a 1, 600-kcal diet and intensive insulin therapy was performed. GAD antibody became positive 15 months after the start of IFN therapy, and disappeared 27 months after the start of IFN therapy. Insulin secretion was depleted and the patient had HLA-DR4, B54, and DRB1*0405. This appears to be a case of type 1 diabetes mellitus induced by administration of IFN-β alone.
(Internal Medicine 39: 146-149, 2000)

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