Internal Medicine
Fusion of the Nucleoporin Gene, NUP98, and the Putative RNA Helicase Gene, DZXX10, by Inversion 11 (p15q22) Chromosome Translocation in a Patient with Etoposide-related Myelodysplastic Syndrome
Katsuyuki NAKAOMaki NISHINOKyoko TAKEUCHIMasayasu IWATAAkira KAWANOYasuhito ARAIMisao OHKI
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Volume 39 (2000) Issue 5 Pages 412-415

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Abstract

We report a 50-year-old man who developed therapyrelated myelodysplastic syndrome after treatment with etoposide-including chemotherapy for extratesticular germ cell tumor. Chromosomal analysis showed inversion 11 (p15q22) translocation. Reverse transcriptase-polymerase chain reaction amplification of patient RNA showed a fusion transcript of nucleoporin gene NUP98, and putative DEAD-box RNA helicase gene DDX10. NUP98 is implicated in the transformation through aberrant nucleocytoplasmic transport. DDX10 is suggested to be involved in ribosome assembly. The NUP98-DDX10 fusion transcript may promote the development of secondary hematological malignancies caused by DNA-topoisomerase II inhibitors through aberrant nucleocytoplasmic transport and/or alteration in ribosome assembly.
(Internal Medicine 39: 412-415, 2000)

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