A Patient with Cyclic Neutropenia Complicated by Severe Persistent Neutropenia Successfully Delivered a Healthy Baby

Abstract

We describe a 24-year-old pregnant woman complicated by cyclic neutropenia (CN), who was successfully treated with granulocyte-colony stimulating factor (G-CSF). Her white blood cell (WBC) and neutrophil count fluctuated from 2, 600 to 4, 600/μl, and 26 to 2, 530/μl, respectively. The peak neutrophil count gradually decreased as pregnancy advanced, resulting in the disappearance of its cyclicity. At 39 weeks of pregnancy when the neutrophil count became 84/μl, the patient was started on G-CSF and her neutrophil count increased to 1, 550/μl on the fourth day after delivery. She delivered a healthy baby without any complications at 39 weeks of pregnancy.
(Internal Medicine 39: 663-666, 2000)