Pulmonary Lymphoma of Large B-cell Type Mimicking Wegener's Granulomatosis

Nobuaki MIYAHARA; Ryosuke EDA; Yoshiki UMEMORI; Tomoyuki MURAKAMI; Naomi KUNICHIKA; Kiyoshi MAKIHATA; Keisuke AOE; Kazuo MURAKAMI; Hiroyasu TAKEYAMA; Mine HARADA

doi:10.2169/internalmedicine.40.786

Nobuaki MIYAHARA, Ryosuke EDA, Yoshiki UMEMORI, Tomoyuki MURAKAMI, Naomi KUNICHIKA, Kiyoshi MAKIHATA, Keisuke AOE, Kazuo MURAKAMI, Hiroyasu TAKEYAMA, Mine HARADA

Author information

Nobuaki MIYAHARA
the Second Department of Medicine, Okayama University Medical School
Ryosuke EDA
the Departments of Medicine, Respiratory Disease Center, National Sanyo Hospital
Yoshiki UMEMORI
the Departments of Surgery, Respiratory Disease Center, National Sanyo Hospital
Tomoyuki MURAKAMI
the Departments of Pathology, Respiratory Disease Center, National Sanyo Hospital
Naomi KUNICHIKA
the Departments of Medicine, Respiratory Disease Center, National Sanyo Hospital
Kiyoshi MAKIHATA
the Departments of Medicine, Respiratory Disease Center, National Sanyo Hospital
Keisuke AOE
the Departments of Medicine, Respiratory Disease Center, National Sanyo Hospital
Kazuo MURAKAMI
the Departments of Medicine, Respiratory Disease Center, National Sanyo Hospital
Hiroyasu TAKEYAMA
the Departments of Medicine, Respiratory Disease Center, National Sanyo Hospital
Mine HARADA
the Second Department of Medicine, Okayama University Medical School

Keywords: non-Hodgkin's lymphoma, lung, large-cell type

JOURNAL FREE ACCESS

2001 Volume 40 Issue 8 Pages 786-790

DOI https://doi.org/10.2169/internalmedicine.40.786

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Abstract

A 27-year-old man with a primary pulmonary lymphoma of large B-cell type is described. Symptoms involved both the upper and lower respiratory tract. A chest roentgenogram showed a dense mass with cavitation. Transbronchial biopsy specimens revealed no atypical cells, rather they demonstrated granulomatous infiltration and vasculitis consistent with but not conclusively diagnostic of Wegener's granulomatosis. The pulmonary mass became smaller after sulfamethoxazole-trimethoprim therapy. These features suggested Wegener's granulomatosis. However, an open biopsy specimen was diagnostic for diffuse lymphoma of large B-cell type. High-grade pulmonary lymphoma should be considered in the differential diagnosis of patients with clinical and pathologic features suggesting Wegener's granulomatosis.
(Internal Medicine 40: 786-790, 2001)

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