PTHrP-producing Tumor: Squamous Cell Carcinoma of the Liver Accompanied by Humoral Hypercalcemia of Malignancy, Increased IL-6 and Leukocytosis

Nobuyuki ASANUMA; Keisuke HAGIWARA; Ikuko MATSUMOTO; Masahiro MATSUDA; Fumiaki NAKAMURA; Haruhiko KOUHARA; Makoto MIYAMOTO; Yoshihiro MIYASHITA; Sanai NOGUCHI; Yasuhiko MORIMOTO

doi:10.2169/internalmedicine.41.371

Nobuyuki ASANUMA, Keisuke HAGIWARA, Ikuko MATSUMOTO, Masahiro MATSUDA, Fumiaki NAKAMURA, Haruhiko KOUHARA, Makoto MIYAMOTO, Yoshihiro MIYASHITA, Sanai NOGUCHI, Yasuhiko MORIMOTO

Author information

Nobuyuki ASANUMA
The Department of Internal Medicine, Aizenbashi Hospital
Keisuke HAGIWARA
The Department of Internal Medicine, Aizenbashi Hospital
Ikuko MATSUMOTO
The Department of Internal Medicine, Aizenbashi Hospital
Masahiro MATSUDA
The Department of Internal Medicine, Aizenbashi Hospital
Fumiaki NAKAMURA
The Department of Internal Medicine, Aizenbashi Hospital
Haruhiko KOUHARA
The Departments of Endocrinology, Osaka University Hospital
Makoto MIYAMOTO
The Departments of Pathology, Osaka University Hospital
Yoshihiro MIYASHITA
The Department of Internal Medicine, Aizenbashi Hospital
Sanai NOGUCHI
The Department of Internal Medicine, Aizenbashi Hospital
Yasuhiko MORIMOTO
The Department of Internal Medicine, Aizenbashi Hospital

Keywords: calcium, parathyroid hormone, cytokine, liver cyst

JOURNAL FREE ACCESS

2002 Volume 41 Issue 5 Pages 371-376

DOI https://doi.org/10.2169/internalmedicine.41.371

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Abstract

A 77-year-old man was admitted to our hospital showing symptoms of general fatigue and appetite loss. He had leukocytosis, thrombocytosis and hypercalcemia with elevated serum levels of parathyroid hormone related peptide (PTHrP) and interIeukin-6 (IL-6). An increase in tumor markers SCC and CYFURA21-1 was observed. The liver contained a huge tumor, which was proved to be PTHrP producing squamous cell carcinoma by immuno-histochemical analysis. Since the tumor did not express IL-6, it was assumed to be induced by PTHrP in osteoblasts. This is the first report of PTHrP producing squamous cell carcinoma of the liver.
(Internal Medicine 41: 371-376, 2002)

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