Abstract
In order to study the conditions of thyroid functions, convection ratio of protein-bound plasma iodine was studied and the cor relations between the convertion ratio and the clinical symptoms, the basal metabolic ratio and the thyroid-up-take ratio were examined. Changes of convertion ratio by time were also observed. The procedures were as follows;
1. More than 500μc of I131 were administered orally
2. By 24 hours, blood was taken, to which dioxalic acid was added
3. Serum was centrifuged
4. Total plasma I131 was determined by Clark-Moore-Adams-method, protein-bound plasma iodine by the Chaikoff-Taurog-Beinhardt-method
5. Radio activity was determined by Scintillation Counter.
Results were as follows;
1. Overlapping convertion ratios of normal thyroid and hyperfunctioning thyroid was less than that of thyroid-up-take ratio of I131 that means that the procedure is an effective indicator of thyroid functions.
2. The high correlations between convertion ratio and basal metabolic ratio or thyroid-up-take ratio were observed.
3. Total plasma I131 increased rapidly during the initial period and reached at peak within one and half hour. It decreased rapidly for a short time and continued to decrease slowly.
4. Convertion ratio increased consistently for 24 hours.
5. There was no correlation between convertion ratio and the increase of lymphocytes or blood-sager contents.
