Abstract
Emulsified oleum hydnocarpi with sodium salt of oleic acid has marked bacteriostatic and bacteriocidal activities on human tubercle bacilli.
The emulsified oil was found to exert inhibition or retardation of the growth of small inocula of human tubercle bacilli (Frankfurt strain) in Kirchner synthetic sera media. Results obtained were as follows:
With 1% bacteriocidal, with 0.1% bacteriostatic, completly and with 0.01% bacteriostatic, incompletly.
Oleic acid (C17H33COOH) exerts dual effects on tubercle bacilli, generally, their sodium salts and hydnophobic esters (glycerides) will not be utilized by bacteria, without influences of concentration and milieu, i. e., existence of serum albumin, potato starch and charcoal.
The emulsified oil took the admixture, 1 part of 10% sodium salt solution of oleic acid and 3 parts of oleum hydnocarpi (pH 7.0), and then it obtained chemical equilibrium and fusible action for caseous lesions due to the surface active action of sodium salt of oleic acid.
Ten ml of the emulsified oil, mixed with each 1ml of distilled water with 250mg of INH and 50mg of Teben, were injected into pulmonary tubercular cavities and bronchial ulcer by Nelaton's or Metras sonde, approximately 30 to 50 times twice weekly.
It was found that reduction of the cavity in 1 case, cicatricial changes of bronchial ulcer in 1 case, inclination of bacilli negative results in bacteriological cultures of sputa and improvement of general symptoms in 3 cases, with exception of 1 case in which emulsified oil could not reach the tuberculous lesions because of intense coughing at the injection.
At present, it may be inadequate to estimate the therapeutic effect, because of the more scanty cases and no observation of the long-range outcomes.
The present paper described the effects of emulsified oleum hydnocarpi with sodium salt of oleic acid as a basic drugs for direct chemotherapy in tuberculous cavities.
