抄録
The authors injected subcutaneously human type (Kurono strain) tubercle bacilli into femoral part of guinea pigs, and by 59th day, homogeneous transplantation of pituitary bodies was conducted. Simultaneously, for the comparison, another group of guinea pigs were injected with cortisone, 5mg per day, from the 5th day to the 80th day of experimental tuberculosis. All the guinea pigs were autopsied by the 80th day. Results were as follows:
1) In the group of pituitary body transplantation (group 1), activity of epitheloid cells, thick lymphocytes zone, favourable fibrous capsulation and no necrosis were found.
2) In the group of cortisone injection (group 2), blurred margin of lesion, irregular enlargement and strong caseation were found.
3) Part of the cases in both group was simultaneously administered with streptomycin (20mg daily for 20 days) and these cases showed clear curative process, i, e., atrophy and absorption of lesion.
4) As we reported at the East Endocrinological Society, Sept. 25, 1954, homogeneous transplantation of pituitary body seems as effective as growth hormone from anterior pituitary tissue. In the present experiment, we found that the transplantation showed the same effect on the inflammatory lesion as the injection of anterior pituitary hormone.
5) Tuberculosis lesion became worse by cortisone, while the additional streptomycin with proper dose showed remarkably curative tendency. This fact suggests that adreno-cortical deficiency combined with tuberculosis may be cured by the combined treatment of cortisone and streptomycin.
