Abstract
The influence of single or combined continuous administration of SM, PAS, TB1, and or INH on the migration velocity of neutrophile leucocytes of pulmonary tuberculosis was examined and the following results were obtained.
1. Some cases showed decreased migration velocity before the administration. Most cases showed increased migration velocity 10 days after the start of the therapy. It gradually increased and recovered the former value by 1 month, exclusive of the cases administered with PAS alone, which presented lower value than that befor the administration.
2. The increase was marked in those cases that had shown abnormally low migration velocity before the administration. Slight variation was observed in the cases whose values had been nearly normal. Only a few cases showed supernormal value after the treatment and the majority of the cases showed normal level continuously.
3. Relation between clinical findings and the migration velocity differed from case to case. By chemotherapeutics used or methods of administration adopted, no appreciable difference was observed. However, cloose parallelism was found between clinical findings of each case and migration velocity. In the cases where chemotherapy was efficacious, increase of the velocity was also marked.
These results may confirm that migration velocity of leucocytes will increase when antituberculous agents are administered in pulmonary tuberculosis. It is not clear whether this phenomenon is due to direct effect of these agents on the function of leucocytes or to the secondary change evoked by the inhibited growth of TB bacilli.
