Abstract
As described in my previous report, out of 57 patients, resistance was noticed 88.6% to SM, 66.0% to PAS and 52.8% to INH. These patients were treated with PZA 2.Og and INH 0.4g daily for six months.
1) Sputum smear positive into negative-Within one week of the above mentioned therapy we found some sputum smears showed tubercle bacilli positive into negative. This tendency was noticed as maximum after two months therapy. However, we had some cases in which their smear test became positive again, especially after one or two month's therapy. This phenomenon was noticed among 50% of INH resistant strains.
These facts indicate that the efficiency of PZA on tubercle bacilli is quick and consequently it does not last long, therefore no one can expect this to be efficient for a long time. This tendency was particularly remarkable in the INH-resistant strains.
2) Rentogenographic improvement-Most patients had disseminated infiltrates.
(1) INH sensitive group-moderate and marked improvement was found in 4.4% after 3 month's therapy and in 40.0% after 6 month's therapy.
(2) INH resistant group-after 3-6 month's therapy 25 of them showed improvement.
As for cavities no case had cavities that disappeared by 6 month's therapy. However.
(1) INH sensitive group-cavities became smaller in 12% by 3 month's therapy and 24% after 6 month's therapy.
(2) INH-resistant group-only 10.7% showed improvement.
3) Toxicity-Hepatitis was rare among them. Joint pains were 89.5%, hemoptoe was 4.3%, hemosputum 10.6%.
Summarily, PZA-INH therapy for 6 months brings improvement in sputum bacillus test, rentogenographic findings, and general condition of the patients. This indicates we have to observe the patients for a long period of time.
