シヨツクに関する研究特にPlasma Prothrombin Timeの消長について

抄録

Research has been done by the author on the change of the Plasma Prothrombin Time of rabbit's blood obtained by means of cardiac puncture when the rabbits are shocked with various methods. Kato's micromethod was applied and the Prothrombin Index was calculated according to the following formula:
Injections with several kinds of drugs were given to the rabbits before they caused shock. Then each Prothrombin Index at the time of the shock was examined. In an attempt to find out the most effective drugs to control the shock, the following experiments were performed and obtained results were as follow:
1) When no shock is given the Prothrombin Index shows very little change in the course of 30 minutes to 5 hours. However, the Index decreases after 24 hours through 48 hours.
2) In cases of traumatic shock such as injury shock, burn shock, as well as drug shocks such as peptone, acetylcholine and histamine shock, the Prothrombin Index increase is the greatest during the 30 minutes after the shock. After 5 hours of shock the Prothrombin Index decreases steadily and gradually. In case of tourniquet shock, for 30 minutes after the shock the Prothrombin Index did not increase, then it decreases gradually. The acetylcholine-and histamine-shock show little change in the index. The change of Prothrombin Index during tourniquet shock, burn shock, acetylcholine and histamine shock are parallel in degree to the stresses given previously.
3) Before rabbits are shocked various kinds of drugs were administered. Comparison of the Prothrombin Index curve with drugs and the non-shocked curve are made available. +++ indicates markedly effective, ++ effective and + slightly effective. Obtained results are as follow:
Summarily VB₁, VC and V. P. seemed to be most effective drugs.
4) In case of traumatic shock in which the rabbit was administered solutions of VB₁, VC and C. P.; a marked controlling effect was observed. With the drug no marked control was observed.