Abstract
Ogata's Complement-fixing test and V. D. R. L tests were performed on 6, 324 pregnant women, who as out-patients had received medical treatment at the obstetrics and gynecological department of the 2nd Tokyo National Hospital from 1952 to 1958. Ninety of these cases had doubtful positive reactions.
1) Possible infection, seroreaction of parents, husbands and brethren.
2) Diseases with positive seroreaction, shock, pregnancy, and negative seroreaction immediately after delivery seen in these pregnant women were subjected to immunoserological examination.
3) Neonates, fetal blood at the time of delivery, omphalorrhagia, fetal blood after delivery, exanthema found in the placenta, enathema, epithysitis of the long bone and roentgeno gram were observed.
At the same time the difference between their hematochemical variations and those of normal pregnant women was studied before and after delivery. The preceding research confirmed to us that negative seroreaction of pregnant women subject to the abnormal reaction signified by appearance of remarkable omphalorrhagia and retroplacental blood.
Positive variations due to single Ogata's and V. D. R. L test respectively were neverthless negative upon repeated tests. Hematochemical observation revealed that only cholesterine indicated an abnormal titer, while other substances showed no significant difference.
Reason for this abnormal reaction could not be determined, but it is felt that there is much room for further research on this matter.
