At present except for radiation and surgical therapy there is no other curative treatment for cervical cancer.
Comparisons of 5 year follow up results obtained by reviewing the recent literature between surgical and irradiation was done and the author emphasized that irradiation was a major factor in therapy.
As a standard treatment for cervical cancer the intracavitary radium combined with external radiation has been applied and of these the former was realized as being the principal part of the radiation.
Certain well establishing forms of applying radiation technics have been introduced and these principles and detailed technics were discussed among us.
To carry out the local irradiation one of the most essential factors is to devise the most efficient plan in distributing radium sources in the pelvis to obtain good dose distribution.
The well known fact is that some cases have resistance to radiation therapy. If we foretell that a certain case is radioresistant, it would be logical to treat it surgically.
In conclusion, it seems that radium therapy has to be employed more frequently in this country, because in the future this therapy will give better results if we are successful in improving the technics of its application and also the physical measurements of its radiation doses within the pelvis.

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Ogata's Complement-fixing test and V. D. R. L tests were performed on 6, 324 pregnant women, who as out-patients had received medical treatment at the obstetrics and gynecological department of the 2nd Tokyo National Hospital from 1952 to 1958. Ninety of these cases had doubtful positive reactions.
1) Possible infection, seroreaction of parents, husbands and brethren.
2) Diseases with positive seroreaction, shock, pregnancy, and negative seroreaction immediately after delivery seen in these pregnant women were subjected to immunoserological examination.
3) Neonates, fetal blood at the time of delivery, omphalorrhagia, fetal blood after delivery, exanthema found in the placenta, enathema, epithysitis of the long bone and roentgeno gram were observed.
At the same time the difference between their hematochemical variations and those of normal pregnant women was studied before and after delivery. The preceding research confirmed to us that negative seroreaction of pregnant women subject to the abnormal reaction signified by appearance of remarkable omphalorrhagia and retroplacental blood.
Positive variations due to single Ogata's and V. D. R. L test respectively were neverthless negative upon repeated tests. Hematochemical observation revealed that only cholesterine indicated an abnormal titer, while other substances showed no significant difference.
Reason for this abnormal reaction could not be determined, but it is felt that there is much room for further research on this matter.

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In the previous report the author described that a typical anaphylactic shock was able to be produced in mice. As an antigen apply human serum of AB group and as the challenging antigen apply fresh serum with complement activity then shock death took place in the highest per centage.
From the mice who died of the above said shock the histological findings of lung, kidney and liver were described.
One of the most remarkable histological change was noticed in the liver. The same as in acute liver atrophy degeneration of liver cells was found.

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In 1944 Hamman and Rich reported two cases of diffuse interstitial fibrosis of the lungs and this report was the first systemic description of the syndrome referred to as a disease entity.
Fifty-four case of the Hamman-Rich' syndrome were listed in their review of the literature.
Our patient in this report was a male of 45 years old. He became ill in March 1956 with onset of cough productive of sputum, and on September 3, 1955 he was admitted to the Nara National Sanatorium with a diagnosis of suspected pulmonary tuberculosis. The chest-X-ray findings revealed a tuberculous-like pattern. Anti-tuberculous medicine of SM 50g, PAS 1, 800g; and INH 20g was no effective. Routine sputum culture for tubercle bacilli was negative. The patient died 6 months after admission.
Autopsy observation is limited to the heart and the lungs. The lungs weighs 640g in the right side and 800g in the left side. Cut surface of the lungs diffuse infiltration of fibrin and or gray fibrous tissue. The parenchyma was speckled with a moderate amount of anthracotic pigment. Grossly no areas of tumor involement or tuberculous changes were noticed. The heart weighted 310g and was slightly dilated without any distortion of it's gross contour. (The wall of the left ventricle measured 1.5cm and that of the right ventricle measured 0.5cm in thickness.)
Microscopic examination revealed wide-spread interstitial fibrosis of the pulmonary parenchyma in various stages. (The fibrosis was either dense fibrous tissue, or more prominently, rather vascular cell-rich tissue composed mainly of fibroblastic cells infiltrated with inflammatory cells, numerous macrophages and a few giant cells.)
The alveoli in these areas are filled with a number of desquamated epitherial cells and inflammatory cells, revealing the picture of an intraalveolar pneumonitis. Several sections showed remarkably dilated bronchi containing neurophilic leucocytes, plasma cells, and a few eosinophils with no evidence of tuberculosis histologically. No remarkable changes are observed in other organs except or the liver, where miliary necroses were noticed.)
According to the findings described above, this case is considered to be the Hamman-Rich's syndrome,

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Statistical observation was made on 47 cases with hilar cavities of pulmonary tuberculosis hospitalized in the Tochigi National Sanatorium.
Results:
1) Hematoptysis was seen in 29 cases (60%) and positive tubercle bacilli in sputum in 39 cases (60%). Chemotherapy was administered in each case.
2) Twenty-seven cases (62%) had cavities in the left lung and in 33 caaes (80%) cavities were seen in Seg. 6. Thirty cases (64%) had round forms, 70% were thin walled and 97% were soft walled.
3) In order to observe the relationship between chemotherapy and roentgenographical transformation of hilar cavities 40 cases were examined. Seven cases (18%) indicated cavity closure and 10 cases (50%) showed dwindling in the diameter of the cavity.
4) Conversion of negative tubercle bacilli in sputum was noticed on 6 cases within 2 years and the diameter measured on an average of less than 40mm.

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The broncho-lung's containing capacity, as related to improving chest conditions of various kinds of pulmonary tuberculous patients treated by chemo-therapy, was measured in the 3rd, the 6th and the 12th month. Simultaneously, the functional recovery of the treated lungs and compensatory function of the opposite lungs were studied.
Results:
1) Focal disappearance of unilateral infiltrated type with chemo-therapy, causes by the 6th month a 20% increase of the affected lung capacity, accompanied in the opposite side of the lung by a slight decrease of both tidal volume and oxygen uptake. This can be interpreted as the discontinuation, of the compensatory function.
2) In the unilateral cavity disappearance group, in the 6th month a 10% incerease of vital capacity of the affected lung is seen and in the opposite side of lung due to the suspension of compensatory function decrease of each tidal volume and minute volume can be noticed.
3) Focal disappearance of the unilateral lower lobe showed in the 6th month a 15-20% increase of the vital capacity of the affected lung, accompanying distinctive increase of expiration reserve volume and of residual volume rate. However, suspension of compensatory function of the opposite lung does not occur.
4) In the improvement of the unilateral proliferative type focus or movement into sclerosed type, even in the 6th month both healthy and diseased lungs have little influence on their pulmonary function.
5) In bilateral focus group, the exudative side shows less functional improvement that the proliferative side. And when both side have exdudative foci the side, which has a higher grade of recovery, shows slightly better improvement. In case of cavitized tuberculoma no functional change is noticed.
6) In the pleuralcallosity group, slight functional increase of the affected side can be seen as a result of chemo-therapy, the focus in the opposite side of callosity disappears. However, no functional change is seen in the callosity side. If there is both callosity and focus, when the focus disappears this result in only a slight increase of oxygen uptake in the affected callosity side but no trace of compensatory function in the healthy side of the lung is recognized.
7) Judging from the above mentioned facts, in pulmonary tuberculosis, the importance of the physiological classification based upon the lung function as well as the morphological classification, is emphasized.

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Using 26 male guinea-pigs the effect of SM-INH combined therapy for experimental tuberculous meningitis as well as variation of their encephalogram, clinical symptoms, progress, after-effect, surviving days, increase-rate of body weight, tuberculin reaction, result of quantitative bacterialculture and pathological indications were investigated.
Results:
1) Better effecf is obtained by SM-INH combined therapy than the single therapy with SM-INH.
2) Treatment started in the early stage is necessary. Treatment started during the appearance of and or presence of type I is found to be effective, while the treatment started after the appearance of type II or type III is non-effective.
3) Even after the encephalogram comes back to normal with the use of the chemotherapy, there is the possibility of relapse and the continuation of the same type treatment for a certain period is necessitated.
4) Increase-rate of body weight and encephalogram indications coincide for the most part.
5) In a group, which, after the appearance of type I, was treated with SM and INH the tuberculin reaction, which had already turned negative, sustaines with the improvement of encephalogram. While in a group which, after the appearance of type II or type III, was treated with SM and INH the tuberculin reaction turned negative in accordance with the changes on the encephalogram.
6) The number of living bacilli in the brain and the histo-pathological change at the time of death or slaughter coincides for the most part with the encephalogram indications.

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1) Paralytic forms of the tibial and fibular nerves, especially “drop foot” in leprosy, in relation to the site of predilection of these two nerve trunks is described.
2) Five cases of drop foot successfully treated by means of “tibialis posterior transplant” are reported.
3) Post-operative re-education of the limbs concerned is important.

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