Abstract
Originally E, coli was considered as non-pathogenic. Neverthless in many appendicitis cases E, coli was isolated in almost pure culture.
Therefore it was investigated if there is any inflammatory origin about E. coli, here.
In case E. coli was inoculated to the beneath of serious membrane of caecum in guineapig, no matter the E, coli was heterogenic or homogenic to the guinea-pig acute inflammative reaction was observed, but in case the killed bacteria or kaolin was inoculated no inflammation reaction occurred. When the filtrate of E, coli calture was inoculated intra-
venously beforehand then after 24 hours. Suspension of living E, coli was inoculated to caecum wall, phlegmonous inflammation or allergic changes were observed even in 10-6mg dosis.
In cases no previous procedure was performed, no inflammatory process was observed in such minor dosis.
The same result was obtained in the experiment followed by Shwartzmann's method. The fact proved that E, coli which was inoculated to intestinal wall may cause severe inflammatory reaction in even small dosis.
Therefore it could be concluded that even E. coli which is usually thought considered to be non-pathogenic would exibit severe inflammatory character by chance in certain condition.
