重症結核症の研究ことに化学療法の使用法からみた重症仁の要因と, 治療法の検討

抄録

On 1, 170 patients with far advanced chronic pulmonary tuberculosis, the author investigated (1) etiology, . (2) process, and (3) treatment method with chemotherapy. It reveals that the progress of treatment method, with chemotherapy causes a decrease of appearance rate of far advanced chronic pulmonary tuberculosis. For that purpose a comparison was made available: the period from 1953 up to recent when we are able to use so-called combination treatment, such as SM and PAS or SM, PAS and INHD and the period from 1959 to 1952 we were using so-called monotreatmant; the treatment by SM only. The rate of appearance of far advanced chronic pulmonary tuberculosis was indicated to be less in the former.
At the same time other unfavorable factors were found, Comparatively a large number of the patients were either far advanced or in addition they were drug resistent, Some were at home too long, some were out-patients without adequate therapy. And everywhere in Japan the purchase of antituberculous medicine is not under good control.
These seems to be some of the sources of the etiology of patients with far advanced pulmonary tuberculosis.
The author also experienced the use of a new method for patients with far advan ced puhnonary tuberculosis who seemed hard to cure with the chemotherapeuticc agents such as INHD or SM. Expecting to improve the function in the host, depressed by tuberculous toxic substances, Orotic Acid, Panthotenic Acid, and Thioctic Acid were applied in addition to the chemotherapeutic agents.
This combined method seemed to be effective not only to improve the liver function but also the blood picture and the body weight.