抄録
Clinical and serological investigation of the recipients given two kind of measles virus vaccines were described. One of them was prepared in the Lederle' Laboratory and another one was prepared in Arakawa Laboratory.
One hundred and fourteen susceptible children were vaccinated by the former vaccine and other 41 were given placebo for control, Six hundred and ninety susceptible children were vaccinated by the latter vaccine and other 238 were given placebo for control.
Results is as follows:
1) Lederle' Vaccine:
Main clinical reactions following the vaccination were fever and rash. The average date of the onset of fever was 8.4th day and the mean duration was 3.4 days, As for rash, the onset 10.4th day and it lasted for 3.1 days. And those 86% of vaccinated children showed fever above 37.5°C and 56% showed rash. Mean of the maximum body temperature was found to be 39.2°C.
Meaningful antibody responses were observed in 53% when tested by CF test, and in 79% by means of neutralization test. It was suggested that antibody conversion rate was higher in the cases which showed both fever and rash than those without marked clinical manifestation. This vaccine was felt slightly lower in antibody responses than that follows natural infection, severe complication was found to be rare.
2) Arakawa' Vaccine:
No remarkable reaction were observed following vaccination. Satisfactory antibody responses were observed in 100% both tested by CF and neutralization test.
These results suggested the practical possibility of the measles immunization by live and inactive virus vaccine by the further improvement.
