Abstract
Patients of pulmonary tuberculosis with primary drug resistance during the period from January, 1957 to June, 1962 at the 2nd Hokkaido National Sanatorium were studied clinically and bacteriologically.
The numbers of those patients with a standard resistance showing cultural growth on the medium containing 10γ of Streptomycin, 1γ of PAS, and 1γ of Isoniazid, have been annually increasing, and have ranged 8.8% to the all non-treated cases, and 16.0% to the some cases of cultural positive.
In vitro tests of sensitivity of those patients, there were many such strains with SM and PAS resistance, especially remarkable in SM resistant strains, but none with INH resistance.
In order to compare resistant with non-drug-resistant in the untreated patients, 18 pairs of cases which were similar to sex, age, type of disease, degree and cavity, were analyzed in details as follows after one years' duration treatment.
X-ray finding revealed that the remarkable improvement was noted in non-drug-resistant patients, while the aggravation was noticeable in drug resistant ones.
On the other hand, the high percentage of tuberculosis bacilli culture conversion to negative, were highly observed in non-drug-resistant group, i. e. 89% in non-drug-resistant group, and 61% in resistant one in one years' culture.
The primary resistance of SM has continued through unchangeably or increased higher than those of PAS.
Moreover, observing of process of strains in non-treated patients, SM and INH resistance was more easily obtained in the case of drug-resistant group.
In conclusion, the existence of primary drug resistance made the medical treatment of pulmonary tuberculosis more difficult recently.
