In former reports the cholesterol-lowering effects of jod-preparation and triparanol were described. In this papers we described the de-cholesteremic effects of unsaturated fat, co-enzymatic preparations, glyzyrrhitin and others.
1) There are some effects by unsaturated fat treatment and in this case better effect was observed in treatment than in shorter period treatment.
2) There are good results in cholagogue treatment, but a little effect in tioctic acid therapy and also little effect in pantothenic acid.
3) Good results are obtained in glyzyrrhitin therapy.

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Patients of pulmonary tuberculosis with primary drug resistance during the period from January, 1957 to June, 1962 at the 2nd Hokkaido National Sanatorium were studied clinically and bacteriologically.
The numbers of those patients with a standard resistance showing cultural growth on the medium containing 10γ of Streptomycin, 1γ of PAS, and 1γ of Isoniazid, have been annually increasing, and have ranged 8.8% to the all non-treated cases, and 16.0% to the some cases of cultural positive.
In vitro tests of sensitivity of those patients, there were many such strains with SM and PAS resistance, especially remarkable in SM resistant strains, but none with INH resistance.
In order to compare resistant with non-drug-resistant in the untreated patients, 18 pairs of cases which were similar to sex, age, type of disease, degree and cavity, were analyzed in details as follows after one years' duration treatment.
X-ray finding revealed that the remarkable improvement was noted in non-drug-resistant patients, while the aggravation was noticeable in drug resistant ones.
On the other hand, the high percentage of tuberculosis bacilli culture conversion to negative, were highly observed in non-drug-resistant group, i. e. 89% in non-drug-resistant group, and 61% in resistant one in one years' culture.
The primary resistance of SM has continued through unchangeably or increased higher than those of PAS.
Moreover, observing of process of strains in non-treated patients, SM and INH resistance was more easily obtained in the case of drug-resistant group.
In conclusion, the existence of primary drug resistance made the medical treatment of pulmonary tuberculosis more difficult recently.

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Acute cardiac arrests are experienced at the time of operation in patients with severe diseases, and in our country the permanent cure rate from this condition is only 15.4 per cent.
For past 6 years we have had 10 cases of cardiac arrest to which active treatment such as cadiac massage by thoracotomy was performed.
The primary disease of these patients and number of cases were as follows; pulmonary tuberculosis with ileus 1; pulmonary tuberculosis with acute gastric dilatation 1; pulmonary abscess 1; sarcoma in thoracic cavity 1; pyothorax 2 ; carcinoma of esophagus 2; constrictive pericarditis 1; traumatic rupture of carotid artery 1. Therefore, of these 10 cases, 9 had pulmonary disorders.
As to the main cause of cardiac arrest, in 7 cases anoxia and in 3 cases large amount of bleeding were responsible for this condition. Cardiac standstill was thought to occur by these main causes combining with the other factors such as vago-vagal reflex, coronary insufficiency and others.
Cardiac arrest rarely occurs by one cause, and usually it may occur under the combination of various factors such as anoxia, large amount of bleeding, and vago-vagal reflex, In the cases with large amount of bleeding secondary anoxia occurs, and so in all 10 cases anoxia appears to play an important role for occurrence of cardiac arrest as primary or secondary causes.
The cases with hypofunction of the heart and lungs accompanying with the other bad condition may relatively easily develop anoxia, hence they are. thought to be prepared condition for cardiac standstill.
At the time of operation, specific attention should be paid for oxygen supply, blood transfusion, and especially avoiding burden for cardiac muscles or vago-vagal reflex may be very important points.
The procedures responsible for occurring of vago-vagal refrex were thoracomy in 4 cases, laparotomy in 4 cases, grasping carotid artery in 1 case, and forceful intubation in one. Four cases all developing vago-vagal reflex by laparotomy had pulmonary disorders, This fact indicates that among the cases with pulmonary disorders having anoxia cardiac standstill may occur by laparotomy.
For treatment of cardiac arrest immediate heart massage after thoracotomy and artificial respiration by intubation supplying 100 per cent U2-gas should be done, If ventricular fibrillation may occur electrical counter shock should be applied combining with the other two procedures, In addition to these, medicament should be given as auxilliary treatment.
The brain is the least tolerable organ to anoxia, and it develops irreversible dage if interruption of cerebral blood circulation for 3-4 minutes may occur. In the cases developing anoxia before cardiac arrest, however, the irreversible changes in the brain may develop within 3-4 minutes' interruption of cerebral blood flow, Therefore, heart massage should be done as soon as possible after occurrence of cardiac standstill and the oxygenated blood should be supplied selectively to the brain by the heart massage.

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Six autopsy cases (male 4 cases and female 2 cases) of primary lung cancer during past four years and a half, from April 1958 to September 1962, have been observed.
Initial symptoms were cough, sputum, chest pain, slight fever, hoarse voice, stiff shoulder and lassitude etc.
Roentogenographic diagnosis of the lung cancer of tumor type No. 3 are not so difficult, but that of infiltration type No, 2, 4 and 5 or dissemination type No. 1 and 6 are extremely difficult.
At the outset, therfore, 4 cases of these No. 1, 2, 5 and 6 are misdiagnosed as pulmonary tuberculosis.
Examination of the blood showed the tendency to slight anemia and leucocytosis on the uniformly distributed, wide spread type No. 1, 5 and 6.
Established diagnosis of lung cancer were made by autopsy No. 1 and 2, by lobectomy No. 3 and by biopsy of metastatic focus No, 4 and 5.
The interval from the revelation of the initial symptoms until death were from 8 to 35 months.
Some interesting findings of autopsy were multiple pulmonary air cysts associated with primary lung cancer in the both lung basis of No. 5, and pulmonary tuberculosis (in right S₆) accompanied by tumors in right lung hilus of No. 2.
In histological classification No, 2, 3, 4 and 6 were adenocarcinoma; No, 1 was so-called “alveolar cell carcinoma” with epidermoid carcinoma; No, 5 was undifferentiated carcinoma.

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