結核肺における肺腫瘍の実験的研究

抄録

In a recent study of YAMANAKA, the lung tumors were developed with using carcinogenic substance (20-methylchoianthrene pellets) in the lung of rats, and tumors induction rate was sixty-four per cent.
Present study attempts to induce the experimentally lung tumors in the tuberculous lung of 150 Wistar male rats in this manner.
Living Miwa strain of mycobacteria bovis were suspended 5.0mg per 0.1ml of saline solution, and right lower lobe was injected the suspension with thoracotomy under the ether narcosis of rat.
The pellet consisted of the cholesterol and carbowax 4000, containing 3.4-benzpyrene 2.5mg, was implanted in this place of tuberculous rat.
Adjacent broncheolus of the pellet were proliferation in one or two weeks. It demonstrated squamous metaplasia and keratosis in three or four weeks, also the pellet was surrounded with the squamous metaplasia which contact squamous metaplasia of broncheolus, and it made keratosis.
Squamous metaplasia developed the lung tumor in 17 of 19 (89.5%) from 31 to 78 weeks.
Metastasis and transplantation of the lung tumors were not observed in other organ of rats.
The pellet was found into the lung tumor, and was observed 3.4-benzpyrene by fluorometer.
This lung tumor growth was not inhibited by tuberculous foci.
Similar tumor induction was observed in pellet only implantation group, but other control groups were not observed tumor induction.