Abstract
The recent years the diseases concerning of protein metabolism have been watched with much interest. Authors report a. case of purpura hyperglobuinemica and summarize with the other 13 cases which were reported in Japan. We discuss them about their clinical views, pathogenesis and differentials.
Our experienced purpura hyperglobulinemica case is as follows: this was a 22 years-old female patient with chief complaints of cough, sputum and fever. She had had occasional joint aching and fever since the age of 19-years-old and had been treated as rheumatoid arthritis. In recent 2 years she had had pneumonia on two occasions, and from that time she developed cervical lymphadenopathy, then suffered from painful erythematous lesions at the lower extremities. One month prior to the admission she developed fever and admitted as a bronchopneumonia. She presented accelerated sedimentation rate and marked increased serum protein `which was proved by ptotein fraction and ultra centrifuge analysis, and finally she was diagnosed as purpura hyperglobulinemica by biopsy from cervical lymphnodes and skin, During her hospital stay, she experienced frequent infections, such as pneumonia, frunkulosis at eyelid and facies, otitis media, appendicitis, cystitis, tonsillitis and pharyngitis which were treated by antibiotics. Besides the above several infections she had herpes zoster.
She was treated by Methyl predonisolon and Endoxan against purpura hyperglobulinemica, and discharged in much improved state after 13 months of hospital stay.
