切迫流産のホモルン療法

Chlormadimone acetate試用成績をめぐつて

抄録

The treatment of threatened abortion has been performed almost always by means of hormone therapy centering around progesterone although effectiveness of this approach is doubted by some workers. It is hard to determine whether the given case of threatened abortion is indication of the hormone treatment, however, at the present time in consequence of absence of better therapy, we have to employ this hormone therapy. Chlormadinone acetate shows the strongest luteinizing hormone activity with little side effects, that is suitable for clinical use against threatened abortion. It has been abministered in doses of 6 to 12mg daily for 10 days by the oral route. The following results were obtained by clinical use:
Hemorrhage from the genitalia improved in 8 out of 17 cases by days after the onset of treatment. Hypogastric pain disappeared in 5 out of 9 cases by 5 days. Pregnancy could be maintained in 10 out of 14 cases whose B. B. T. had been elevated or consistently high.
Urinary pregnanediol levels in all cases with the progression abortion were as low as 3mg/day or less, while the said levels tended to rise gradually in the cases maintaining pregnancy. Pregnancy was maintained in all the cases whose vaginal smear showed the pyknosis coefficient of 15% or lower.
After all, the administration of Chlormadinone led to improve the abortive symptom in 12 out of the 17 cases. The drug produced no side effect in the pregnant women and their fetuses.