抄録
The urinary creatine and creatinine were measured in 34 cases of progressive muscular dystrophy.
The increased excretion of creatine was observed in the patients with progressive muscular dystrophy and with other type of muscular atrophy. Even the creatinuria was demonstrated in other type of atrophy and normal human subjects, the output of creatinine in progressive muscular dystrophy was found to be lowered.
The decrease in excretion of creatine was found to correlate with the grade of severity (duration or muscular impairment) in muscular dystrophy.
The creatinuria was invariably encountered in all cases of chronic dystrophy. Pronounced excretion of creatine may physiologically occur even in not only normal subjects but pathological conditions not known to be associated with muscular disease.
Therefore, creatinuria should be less diagnostic for progressive muscular dystrophy.
The decrease in excretion of creatinine in progressive muscular dystrophy is more significant rather than increase in excretion of creatine in its diagnosis.
These results were discussed in relation to the concept that the urinary creatine in that disease represents the creatine newly formed in the liver from which the creatine would have faild to enter muscle.
