Abstract
We isolated 62 staphylococci and 174 Gram-negative bacilli from sputa of the far advanced paimonary tuberculosis patients four times during the period of January to December, 1956. We compared these germs so-called “carried strains” with 150 strains isolated from infectious foci of non-tuberculous patients in our hospital from January, 1964 to December, 1965, and we carried out the sensitivity tests of these two groups of strains.
Results:
1) There is no difference of staphylococci a ndGram-negative bacilli carried by 50 pulmonary tuberculosis patients between four occasions of examination. They carried Staphylococci 32.3%, E, coli 28.6%. Klebsiella 27.6%, Proteus 12.5%, Pseudomonas 8.8% and the others 12.9% in total 192 patients during one year period.
2) In four times' examinations with the lapse of time, the number of patients whocarried the same germ more than twice in succession was 15 in Staphylococci, 13 in E, coli, 9 in Klebsiella, 5 in Proteus and 4 in Pseudomonas. The number of the patients who showed the same resistance Pattern was 6 in Staphylococci, 6 in E, coli, 4 in Klebsiella, 2 in Proteus and 2 in Pseudomonas. Each germ was carried over a few months at the rate of 40-50 per cents.
3) A trend of antibiotic resistance of above mentioned 62 strains of Staphylococci could be observed. The resistance to PC and SX showed the highest percentage. The incidence of the strains resistant to SM was about 50%. They had the high sensitivity to CP, TC and KM. There was no difference between so-called carried strains and the strains obtained from inpatients and the tuberculosis patients, judging from the resistance to PC, SX, SM, EM and KM out of seven antibiotics. The carried strains, however, showed a higher resistance rate to antibiotics than outpatients and patients of non tuberculosis cases. The carried strains had the same trend of the resistance to one or two antibiotics as the strains obtained from inpatients and tuberculosis patients.
4) we recognized that the strains which were obtained from outpatients and patients of non tuberculosis cases showed the resistance to PC for the most, judging from the resistance pattern. Next this resistance proceeded to SM. But the resistance of the strains obtained from inpatients and tuberculosis patients proceeded mainly from SM to EM by way of PC. The carried strains proceeded between the above mentioned two patterns. It was considered as the first stage of development of resistance to KM that “PC-KM resistance pattern” was observed in the carried strains.
5) The sensitivity of carried Gram-negative bacilli to antibiotics-PC, SX and EM-was found extremely scarce. The incidence of antibiotic resistance of this germ was more than 76%, except for E, coli 58.1%. E, coli showed a comparatively low rate of resistance to CL, KM, just as Pseudomaonas to CL. The rate of Proteus resistance to SM was 45.8%, and this germ showed the resistance to seven antibiotics more than 55%. Observing the resistance to various kinds of antibiotics-as far as SM, CP and TC were concerned-we noticed that Pseudomonas showed the highest resistance rate of 41.1%, secondarily E. coli showed 21.8%.
