抄録
We studied 68 cases of blood transfusion in which 66 of them had had resectional therapy or thoracoplasty for pulmonary tuberculosis, and 2 of them had had resectional therapy for bronchiectasis and pulmonary supuration.
They were divided into two groups; 1) γ-Globulin group of 33 cases to which γ-Globulin were given on the day and the next day of the blood transfusion, and 2) control group of 35 cases to which γ-Globulin were not given.
The purpose of this paper is to report the prophylactic effect of γ-Globulin against posttransfusion hepatitis with reference to our serial studies on post-transfusion hepatitis. 100 mg/ml γ-Globulin solution, in amount of 0.12 ml/kg of body weight, was injected, a half amount on the day and the rest on the next day of the transfusion.
Liver function tests were done within one week before transfusion and once a week after transfusion for the first month, and once a month thereafter for 5 months.
Results:
Abnormally high titers of serum colloid reaction were seen mostly in earlier period after the transfusion. This fact was also seen in the other cases which underwent operations without blood transfusion. These variations were considered not to be related with the clinical symptoms or elevated serum transaminase titers which appeared therafter. The variation of the serum transaminase titers was remarkable in a case which had a titer higher than 100 U. during the test period. The variation of SGOT was seemed to be corelated with that of SGPT.
If any remarkable change of SGPT titer occured, it was usually found in the second month. Pathological findings in several liver biopsies which were conducted simultaneously in such cases indicated hepatitis. In the γ-Globulin group, the variation occured usually in the earlier period of the second month. In the control group, it occured at variable period through the second and third month. In the γ-Globulin group the highest titer of each case was less than 500 U., while in the control group some cases showed a titer higher than 500 U.
Hepatitis occured in 42% of the cases in the γ-Globulin group, and in 48% in the control group. Jaundice appeared in 6 cases (17%) in the control group, and none in the γ-Globulin group.
Our results indicate γ-Globulin used at the time of transfusion have some effect against post-transfusion hepatitis. Dose and dosage of γ-Globulin must be studied further more to obtain better results.
