1968 年 22 巻 12 号 p. 1379-1385
Since Minot et al. reported the excretion of compounds containing pentowe and phosphor rus into the urines of patients with progressive muscular dystrophy (PMD) in 1949, several papers were published on this problem, but no definite conclusion has been obtained whether the pentosuria represents a characteristic of PMD.
I was able to identify that 6 out of 70 PMD patients excreted a substance of nucleotide nature in urine by employing a conventional column chromatographic technique with Dowex resin instead of applying the osazon test which had been used by the previous investigators. The substance could succesfully be isolated and partially purified. Analytical data showed that the compound contained ribose, phosphorus and a base component. The base component did not coincide with any known bases of nucleic acid. A second sugar component other than ribose was also detected in the sample. Further investigations are required for the identification of the extract formula of the compound (s).
The amount of the compound excreted in the urine fluctuated significantly from day to day.