For the purpose of evaluating the histogenesis and developmental process of carcinoma of the cervix, 550 cases of benign cervices, 103 cases of borderline lesions and carcinoma in situ, and 72 cases of early invasive carcinoma were histologically studied.
In benign cervix, between squamous and colummar epithelium, there is transitional zone, which epithelial component is all stages of growing process of reserve cells.
These proliferating reserve cells are supposed to be the probable source of early malignant change, because of its location and morphologic resemblance to dysplasia and beginning in situ.
When early stromal invasion occurs, the histological differentiation should be made, whether the invading foci has evidence of proliferation.
The former should be treated radically, its invasive character being similar to the ad_d vanced cancer, while the latter may be treated as carcinoma in situ.
