抄録
Minimal inhibitory concentration of isoxazole to the growth of the strains isolated from sputa of pulmonary tuberculous patients treated with it was higher than those of other sulfonamides in the reported experiment.
An experiment was done on the strains isolated from sputa of pulmonary tuberculous patients who were excreting tuberculous bacilli in spite of the treatment with specific sulfonamides for a long time. Media used were 1% Ogawa's egg slant and Kirchner's semi-liquid agar media with albumin at the rate of 10%.
The cross resistance and the power to Myc, tuberculosis were compared between sulfonamides already used and those never used in a correlation diagram and a histogram of minimal inhibitory concentration to the growth of Myc, tuberculosis at 3 weeks culture.
14 strains isolated from the sputa of pulmonary tuberculous patients treated with sulfisoxazole, 7 strains isolated from those treated with sulfamonomethoxin, 3 strains isolated from those treated with sulfadimethoxin and, as a control, H37Rv were used.
6 sulfonamides were used, that is, sulfisoxazole, sulfamethizole, sulfamezole, sulfamonomethoxin, sulfadimethoxin and sulfamethomidin.
1) Sulfamonomethoxin was most powerful to strain treated with specific sulfonamides in the used 6 sulfonamides.
2) The cross resistance may exist between different sulfonamides on Myc, tuberculosis, Also the one-way cross resistance between isoxazole and diazin may exist, too.
