Abstract
During recent three years, we experienced six cases of young children suffered from hypoplastic anaemia which had been treated with combined oral medication of adrenocortical steroids and anabolic hormone. 4 cases were idiopathic type and other 2 cases were pancytopenic type.
We treated them with the middle dose level, which initially 2-1mg/kg/day of predonisolone for 1-2 months, and after that reduced finally to intermittens administration, also combined with anabolic hormone (Oxymetholone or Methandrostenolone) 1mg/kg/day for several years. In addition to these medication, we treated with the blood transfusion at initial period.
As results of this treatment, 3 cases had a remarkable effect and are survive, 1 case had a moderate effect, and 2 cases with pancytopenia (2-years-old and 4-years-old girls) had no effect. Thus the effective rate was 66% and the survival rate was 50%.
This treatment may improve the regeneration of the haematopoiesis in the bone marrow slowly, although corticosteroids will recover rapidly the poor general condition, (fever, anorexia or haemo-rhagic tendency, ) and in addition stimulate the haematopoietic activity of the bone marrow at early time. At the same time the anabolic hormone will increase the production of “erythropoietin”in the bone marrow, but will not be effective for the thrombopoiesis.
As the side effect of this treatment, androgenic manifestation was common, but we took pre-caution against the susceptibility for bacterial or viral infections and liver damage (elevation of GOT, GPT-titer), as well as vulnerability of the treatment of leucaemia.
