Abstract
According to the FAB classification, acute myelogenous leukemia (AML) is divided into M1 and M2 by its degree of differentiation. We classified 98 cases of acute leukemia based on FAB classification and analysed 45 cases of AML. Of 45 cases only 34 could be analysed morphologically and clinically. There were 16 cases of M1, 9 males and 7 females, ages were between 13 and 83, mean 45.2, and 18 cases of M2, 13 males and 5 females, ages between 6 and 80, mean 45.4. The WBC count at the time of diagnosis was 2, 100 to 400, 000, mean 67, 800 in M1 and 3800 to 88, 800, mean 16, 500 in M2. The cases of more than 50, 000 of WBC were 6 in M1 and only 1 in M2. In the bone marrow, mean nucleated cell count was 542, 000 in M1 and 235, 000 in M2 and leukemic cells occupied 77% in M1 and 52% in M2. Hemoglobin value was 6.6±2.5g/dl in M1 and 7.9±2.7g/dl in M2. Erythroblasts remain 4.7% in M1 and 10.3% in M2. In response to chemotherapy, the complete remission was established in 50% of all cases of M1 and M2, but median survival was longer in M2, as M2 was 327 days compared to 248 days for M1. Because there are some differences between M1 and M2, it is useful to separate the two. In some cases, however, it is difficult to distinguish between M1 and M2. Thus, a more clear criteria need to be established.
