Abstract
A case of diabetes insipidus associated with ulcerative colitis has not been reported yet. A 56-year-old man with diabetes insipidus had been treated with clofibrate and trichlorme thiazide for about three years since March 1971.
He was admitted to our hospital on December 15, 1978 because of diarrhea, thirst, general malaise, anorexia and a weight loss of 10kg. At the time of admission, the body temperature was 37.5°C and the average volume of urine per day was 3.7 liters. The skin was dry, marked anemia was present and the total serum protein was 5.0g/dl. Liver function and immunoglobulin levels were normal. There was an increase in the erythro-cyte sedimentation rate. A tuberculin skin test was negative and the functions of endo-crine glands (anterior pituitary gland, thyroid gland, and adrenal cortex) were all normal.
Ba enema, endoscopic examination and the biopsy of the colon revealed severe idio-pathic ulcerative colitis in all areas of the colon.
Five μg of DDAVP was administered twice as nose drops, and the volume of urine was decreased to about 1.5 liters per day. Administration of Salazopyrin resulted in disap-pearance of the diarrhea, improvement of the anemia, and normalization of total serum protein. It is considered that idiopathic ulcerative colitis is an incidental complication during the course of diabets insipidus
