Abstract
In the initial intensive chemotherapy for primary pulmonary tuberculosis, there are very few cases whose tubercle bacilli in sputum did not disappear.
The purpose of this study was to analyze the causes of failure and relapse treated with SHR or HER regimens in original cases.
The 50 patients (33 cases of bacteriological failure during chemotherapy and 17 cases of relapse after stopping) were analysed. On the retreatment of the relapses, it is well known that the same regimens as initials were available and a high level of success was again achieved, because nearly all the patients who relapsed did so with the strain fully sensitive to H and R.
But in our research some patients acquired the resistance to both drugs during chemotherapy and after stopping. One of the causes of failure was the drug-resistance acquired in the early stage of chemotherapy. Some medical complications (diabetes mellitus, pneumoconiosis, chronic hepatitis and asthma etc.) and some accident (hemoptysis, stress and disorder of daily life etc.) were also the causes of increasing failure and relapse.
In retreated-cases and previously treated cases, we had the same results as in primary treated cases.
