Abstract
A study of chromosome in five patients with congenital muscular dystrophy was per-formed. The lymphocytes from peripheral blood were cultured in a folic acid-deficient culture medium. The presence of the fragile site in 2% or more of the metaphases was judged as positive. The fragile site at 6q12 or 13 was found in a patient with Fukuyama type congenital muscular dystrophy (FCMD). Because viral etiology was postulated for FCMD, we considered that the presence of the fragile site might be associated with FCMD. Thus, many patients with FCMD should be studied for the fragile site.
