Abstract
According to the treatment protocol of the research group of the Ministry of Health and Welfare, we treated 3 cases of chronic ITP of the children with danazol, who did not undergo splenectomy. All were given 200 mg of danazol daily, whereas the other factors such as age, duration of the disease, efficiency of previous treatment, and the duration of danazol administration, were different among the 3 cases. The treatment with danazol turned out to be ineffective in all three cases, which showed no or transient increase in platelet count, and no improvement of clinical symptoms including purpura. Although on subjective side effects were observed, elevation of alkaline-phosphatase was seen in 2 cases. The guide does not include examination of γ-GTP, LAP, Na, K, which should be examined from now on. Since the mechanisms of the action of danazol are not known, we think it is necessary to experience many cases in order to discuss the feasibility and efficacy of danazol in the treatment of ITP of the children.
