Abstract
Recently, therapeutic drug monitoring (TDM) has been introduced to many hospitals to control drug therapy appropriately. In this study, we have presented the TDM at Kure National Hospital.
If a doctor wants to know the drug concentration of in or outpatient, and then he brings the whole blood of the patient to the pharmacist office, a pharmacist assays the sample at any time. This is a strong point in this hospital. The data is sent to the doctor as soon as possible. Routinely, we have assayed the concentration of phenytoin, phenobarbital, carbamazepine, sodium valproate, digoxin, theophylline, gentacin, amikacin and lithium.
We have done data analysis according to, the general therapeutic range and analyzed by microcomputer and have determined the dosage after conference with the doctor with consideration of clinical state of the patient.
We have given the doctor the predictive concentration after changing dosage form or administration route. We are presently studying this correlation of drug. Concentration by different administration routes using experimental animals. It is important to communicate with medical members, doctors and nurses to further develop the TDM system.
