Abstract
The pathogenic factors were investigated in patients with anti-HBs antibody positive chronic liver disease. In patients with chronic HBV hepatitis, the liver cell damage and liver function are considered to improve during the seroconversion from HBs antigen to anti-HBs antibody. For cases with anti-HBs antibody positive active chronic liver disease, the pathogenic factors should be considered other than HBV infection.
In our 45 cases with anti-HBs antibody positive active chronic liver disease, the incidence of patients with alcohol abuse, blood recipient, serum autoantibody positive and without these episodes were 54.5%, 21.9%, 23.8% and 16.9%, respectively.
In our study, the highest incidence of haptoglobin 2-2 occured in cryptogenic cases, although the incidence of haptoglobin phenotype in patients with anti-HBs antibody positive active chronic liver disease was comparable with that of the Japanese population. The incidence of haptoglobin 1-1 in cryptogenic cases was found different between our study and the European study.
