Abstract
The excretion values of polyamine in the urine of 207 patients with breast carcinoma, 14 patients with benign breast diseases and 44 normal subjects were studied especially in relation to their alteration by the extension of malignancy in breast carcinoma patients.
Urinary polyamine was not significantly elevated during early stages, but it was elevated in advanced stages of breast carcinoma. Excretion values of polyamine in the urine of patients with breast carcinoma without lymphnode metastasis and recurrence were 57.4±74.4 (positivity 74.8%) and 93.3±67.0 (100%) μmol/g. crnn, respectively. The results suggest measruement of urinary polyamine may be of value in monitoring tumor progression and metastatic invovlement.
