Abstract
A prospective study was conducted among third trimester pregnant women to determine incidence of vaginal colonization with group B streptococci (GBS) and influence of antibiotic treatment and vaginal douche with povidone-iodine on subsequent vaginal colonizations. One hundred and fourteen women were found to be colonized among 2, 360 cultured (4.8%) women. Reduction in colonization was noted more frequently in antibiotics treated group (AMPC or IPABPC, 1000mg/day, 7 days, per os) than in vaginal-douche group and non-treated group (p<0.01), but recolonization of GBS was observed in 25% of the women who had turned negative in culture with the treatment. By agglutination method, serotype of GBS strains obtained from vaginal flora was as follows; Ia: 28%, Ib: 22%, II: 18%, III: 9%. The colonization rate of GBS was higher in the infants born to the mothers who had been persistent positive or repositive in vaginal culture than in those born to the mothers who had been negative with treatment. This data suggested that administration of antibiotics to GBS carriage women just prior to the delivery was important to prevent GBS transmission to infants.
