Abstract
Seventy-four cases of cadaveric renal transplant recipients were evaluated about the occurrence of acute tubular necrosis (ATN) which is the one of the postoperative complications of renal transplantation. Machine perfusion method was used with several cold preservation solution (Collins, UW or CMH solution) at the removal of the renal grafts from 60 donors. Drip infusion method with Collins solution was used in fourteen donors. ATN developed in 11 and primary nonf unction kidnyes in three out of 14 recipients whose graft were perfused by drip infusion method. The renal function was immediately recovered after transplant operation in the 11, ATN developed in 42 and primary nonfunction kidneys in 7 out of the recipients whose grafts were perfused by machine method.
In 11 recipients who did not suffer from ATN, warm ischemic time was less than 25 minutes. The recovery of serum creatinine after renal transplantation seemed to be good in the recipients who were not or less required to have hemodialysis after transplantation due to the ATN. The actuarial survival rate of renal grafts without occurrence of ATN was significantly better than the rate of renal grafts with occurrence of ATN. In conclusion, in order to improve the graft survival rate it is necessary to prevent the occurrence of ATN and to increase the viability of the renal grafts by using new cold preservation solution.
