TB-1の肺結核患者肝機能に及ぼす影響

抄録

TB-I therapy, for a period of 10 weeks, were studied on 27 tuberculous patients at the Second Hokkaido National Sanatorium.
In the cases administered with TB-I; the presence of disturbances of liver function and its occurence in time, was searched through the examination of liver function and reached the conclusion as follows:
1) A marked disturbance of liver function was not found by serial administration of TB-I gradually increased (the maximum dose 100mg); in a couple of cases only a temporary and slight disturbance was observed and in very few cases, a tendency for improvement was found.
In general, in the Hepatosulphalein test, a temporary and slight disturbances occured in several cases and 4 showed improvement.
Also in cases of the serum cobalt reaction and the serum cadmium reaction, a remarkable disturbance of liver function was not found. However, in a few cases, tendency for improvement was found,
In the urine no marked changes of urobilinogen reaction were found.
2) In the second to the sixth week, after administration of TB-I, the disturbances of liver function were found most frequently, then tended gradually to a recovery or improvement. With TB-I treatment, the disturbances were observed most frequently in the following period; in the Hepatosulphalein test, about in the second to the sixth week; in the cobalt reaction, about in the sixth week. On the other hand, no particular period of disturbances by administration of TB-I was shown in the urobilinogen reaction of urine