Abstract
Previously we reported that 6 of 13 cases of cold abscess of the chest wall were completely cured with interval injections of Streptomycin (SM) directly in to the lesion after aspirating the pus. We used Streptokinase (SK), Streptodornase (SD) with isonicotinic acid hydrazide (INAH) and SM on 9 cases of this condition. 1.0cc (SK 10.000U. SD 25.000U.) of SK and SD (varidase “Lederle”) disolved in 10cc of normal saline solution was used as an initial dose increasing its amount as time went on.
The method of the application is as follows:
1) After injection of Varidase, aspiration of pus and injection of antituberculous medication was repeated.
2) After a small incision was made over the abscess and the cleaning of the pus and granulation was carried out varidase was injected into the abscess.
3) Instillation of medication was done into the fistula and on the ulcerated area after the spontaneous rupture of the abscess. Following the injection of Varidase into the abscess, a local heat was noted and pain, fever, dizziness and headaches were complained of by patient and sometimes the abscess became enlarged and ruptured spontaneously. Occasionally no signs of easing of the lesion were noted even after the aspiration of pus and repeated use of Varidase. In such cases an operation should be done.
The poor result in the use of Varidase for abscesses and fistulae is caused by: 1) when abscess extend behind the ribs, 2) when caries of the ribs is present. 3) When granulations and Gaseous masses could not be completely irradicated by the use of Varidase. Following the use of Varidase the permeability of the abscess wall may be increased due to the leftover rays of the injected phosphorous isotope (p32.).
