Abstract
Experiments were carried out on patients who have history of having had edema on the extremities when exposed to cold. Following drugs were injected to these patients: autonomic stimulants and anaesthetics, sympathetic ganglion broking agents, antihistaminics, and other drugs which are considered to be effective for motor nerves and permeability of blood vessel. After 1cc of these drugs was injected forearm or thigh the area of the injection was immersed into water. In the A group edema could be produced merely by immersing the extremity into cold water (18°C), while that of B could not be caused without applying ice it was necessary to apply ice on the thigh for 7 minutes to produce edema. Once it developed, the edema did not dissapear for 6 hours. The drugs refered to were used to protect from causing edema.
1) Inhibitiory drugs
Such sympathetic stimulants as adrenalin, ephedrin and methylephedrin, such antihistamines as anahist, benadrin and anergen, showed clearly their effectiveness. Strange enough such sympathetic anaesthetic agents as Imidalin also showed the same inhibitory effect.
2) Inhibitory time
The Efficiency was estimated by the time required for the appearance of oedema.
3) Areas of edema inhibition
Patient A
There are no great differences in the area involued among these drugs. They have shown a dent from 1.5 cm to 1 cm (diameter) according to the inhibition power.
Patient B
The differences are of area involved is greater in B group than A group.
