Experiments were carried out on patients who have history of having had edema on the extremities when exposed to cold. Following drugs were injected to these patients: autonomic stimulants and anaesthetics, sympathetic ganglion broking agents, antihistaminics, and other drugs which are considered to be effective for motor nerves and permeability of blood vessel. After 1cc of these drugs was injected forearm or thigh the area of the injection was immersed into water. In the A group edema could be produced merely by immersing the extremity into cold water (18°C), while that of B could not be caused without applying ice it was necessary to apply ice on the thigh for 7 minutes to produce edema. Once it developed, the edema did not dissapear for 6 hours. The drugs refered to were used to protect from causing edema.
1) Inhibitiory drugs
Such sympathetic stimulants as adrenalin, ephedrin and methylephedrin, such antihistamines as anahist, benadrin and anergen, showed clearly their effectiveness. Strange enough such sympathetic anaesthetic agents as Imidalin also showed the same inhibitory effect.
2) Inhibitory time
The Efficiency was estimated by the time required for the appearance of oedema.
3) Areas of edema inhibition
Patient A
There are no great differences in the area involued among these drugs. They have shown a dent from 1.5 cm to 1 cm (diameter) according to the inhibition power.
Patient B
The differences are of area involved is greater in B group than A group.

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Upon subarachinoideal air-infusion a decrease of eosinophile cells and lymphocytes is noted.
As to the mechanism of this effect we are obliged to think of the influences of the pituitary-adrenal-system or of blood regulation nerves in addition of the simple mechanical ablation of tissues.

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Concerning a pattern of pulmonary tuberculous, I have, for the past few years, examined the influences of “renewal substance of tuberculous bacilli” against other various bacillus in test tubes. I have already reported some of the results of my study.
Now, I have also examined the influences of a distillate in a filtrated tuberculous bacilli and compared them to other various bacilli from the standpoint of growth.
The results are as follows:
1) It is recognized that “T. B.” distillate, which is made by Fr strain or H37RV strain, contains a substance which promote growth, against “pneumonia diplococcus (I type)” and “Staphylococcus aureus (209p)”.
2) Distillate of tuberculous pus is also recognized as having almost the same reaction against “Staphylococcus aureus (209P)”.

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In 12 pneumothoraxs and 14 tuberculous empyemas of the autopsied cases at the Kiyose National Sanatorium, fibrosis of a lung tissue was observed histologically. Used materials were obtained mainly from diseased lobes.
I classified fibrosis of a lung tissue in four stages, and observed it in relation to pleural sclerosis, exsudate and pus of a pleural space, duration of pneumothorax and empyema, opaque lung, and tracheobronchial tuberculosis. Generally speaking, these factors did not lead a tissue to a irreversible stage of fibrosis and fibrosis of a lung tissue seemed to be effectively influenced by a former inflammatory process.
Both of fibrosis of a lung tissue and pleural sclerosis binders a collapsed lung lobe from re-expanding. Recently, decortication or strepto-kinase and-dornase or trypsin has been used successfully on a therapy of tuberculous empyema and unexpandable lung. Regarding to this, we should not forget unperceived or obvious tuberculous foci in collapsed lung, so a use of these treatments must be carefully evaluated.
I discussed indication and contra-indication of these treatments at each stage of pleural sclerosis and fibrosis of lung.
As a summary, I concluded that artificial pneumothorax treatment should be carefully conducted and maintained to avoided empyema.
I discussed on clinical findings of “unexpandable lung”.

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