Abstract
In the preceding two papers, the author reported on the quick and quantitative determination of the drug sensitivity of TB bacilli. As for the clinical applicaticn cf this method, the author conducted the measurement of the sensitivity of TB bacilli, isolated from TB patients, who had been treated with SVI, PAS, TB1, INAH, singularly or in combination. The results were as follows:
In siingle adninistration, the resistant strains of the concentration of above 10 mg per ml were generally measured when the administration of SM amounted at 30g, PAS at 530g, TB
1
, at 6g and INAH at 16g. In proportion to the increase of dosis, the grade of the drug-resistance and its frequency increased, On the other hand, when the drugs were administered in cornbination, the appearance of the resistant strains was inhibited or considerably delayed' Even if the resistant strains developed in the combined administration, the grade and frequency of drug resistance were smaller than in case of single administration. Incidentally, antituberculous drugs shall be administered in combination, in order to inhibit or delay the appearance of the resistant strains.
The quick and quantitative determination of drug ersitivity cf TB bacilli through the slide culture method has a great clinical value in the reliability of its results and its simplicity of technique.
