Abstract
We investigated the synergistic effects of INAH and other antituberculous drugs, regarding their bacteriostatic and bacteriocidal reactions in vitro.
1) The bacteriostatically synergistic effects of Dihydrostreptomycin, PAS, TB1, Vitamin K and Z-Furan, respectively combined with INAH were proved. Vitamin K in the combination of INAH was the only one which showed, though slightly, the bacteriocidally synergistic effects.
2) In the combinations of INAH with the two of the following drugs; Dihydrostreptomycin, PAS and TB1; the combination of INAH, Dihydrostreptomycin and PAS was the most effective one, having the strongest bacteriocidal activity. Other combinations were of weaker effects, less effective compared to the combination of INAH and Dihydrostreptomycin; INAH and Vitamin K; and had no effects upon bacteriocidal activity.
3) The combination of INAH, Dihydrostreppomycin, PAS and TBI was not more effective than that of INAH, Dihydrostreptomycin and PAS.
4) Against INAH-resistant bacilli, the combination of INAH, Dihydrostreptomycin and PAS, more or less, increased the original antimicrobic activity of INAH, while the combination of INAH, Dihydrostreptomycin, PAS and TB1 decreased the original antimicrobic strength of INAH.
5) Against Dihydrotoreptomycin-resistant bacilli, the combination of Dihydrostreptomycin and INAH did not increase the antimicrobic activity of Dihydrostreptomycin.
