Abstract
Gating nanopore devices, which is composed of a nanopore with embedded nanoelectrode, are expected to be one of core devices to realize $1000 genome sequencing technologies, and identify single base molecules via tunneling current between nanoelectrodes. We have demonstrated to identify single base molecules of DNA and RNA using tunneling currents. 2 Core technologies should be developed in an effort to make gating nanopore devices fit for practical use. One core technology is to identify single DNA and RNA composed of many base molecules. We have succeeded in single molecule electrical sequencing of DNA and RNA formed by 3 and 7 base molecules, respectively. A method to control speed of single DNA passing through a nanopore is one core technology to determine speed and accuracy of sequencing. We have developed the method to control translocation speed of single DNA by three orders of magnitude using voltage between nanoelectrodes.
