2021 Volume 60 Issue 5 Pages 468-477
We describe a nanostructure with a physical antibacterial function. Based on the hypothesis of previous studies that the antibacterial function is expressed by adsorption energy, we performed calculations by introducing adsorption energy and bacterial breakage conditions. The calculation results explained the difference in antibacterial effect of the nanostructured film on the bacterial species shown by previous studies. In addition, the antibacterial ability of the pillar structure according to the structural factors was illustrated almost comprehensively. The nanostructured film designed based on this hypothesis was realized by printing and showed antibacterial function. In addition, we measured the temporal changes of bacteria that came into contact with the nanostructured film by fluorescence microscopy, and confirmed the behavior that supported the hypothesis : the cell membrane was attracted to the nanostructured film side. Furthermore, we fabricated finer nanostructured membranes using the same principle for the effect on viruses, and confirmed the expression of the antiviral function.